TNFRSF11A and rheumatoid arthritis: The process of bone remodeling is conformed by RANKL, nuclear factor-κB (RANK), and osteoprotegerin, which is an essential molecular coupling pathway between osteoclasts and osteoblast [20]. A cross-sectional study by Zavala-Cerna involved 82 women with RA, their mean age (50 ± 12) and RA duration (12 ± eight) years, and 52 healthy subjects.