In contrast, a significant difference found in BsmI and TaqI (pc < 0.05) between RA and control group, rheumatoid factor (RF) titers were higher with genotypes (aa and bb), bone loss was high with Bb, C-reactive protein (CRP), and anti-citrullinated peptide (Anti-CCP) were more elevated with aa genotype. The gene discussed is CRP; the disease is rheumatoid arthritis.