SLC5A2 and chronic kidney disease: In the canagliflozin and renal events in diabetes with established nephropathy clinical evaluation (CREDENCE) trial, i.e., estimated GFR of 30 to <90ml/min/1.73m2 or albuminuria clinical evaluation, that was aborted early after the primary endpoints were reached, the SGLT2 inhibitors were effective in delaying the progression of CKD and reducing albuminuria.