Our results are in disagreement with Brovko and colleagues, 2018, who had done a study on 131 CKD Russian patients (stages 1–5, average age 42.4 ± 13.7 years) and revealed that, with univariate analysis, serum sclerostin levels correlated positively with LVM index (r = 0.545; P < 0.01) but with multivariate regression, it was negatively correlated to CVC and suggested that it may protect the heart and vessels against calcification with CKD advancement [40]. The gene discussed is SOST; the disease is chronic kidney disease.