Ayers et al. similarly demonstrated a significant relative increase in oxidative stress for metoprolol compared with nebivolol, as well as differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome measured by F2-isoprostanes, after just a 12-week period of randomization [37]. This evidence concerns the gene SERPINB2 and metabolic syndrome.