CD8A and cancer: In the July issue of Immunity, Xu et al. report that uptake ofoxidized lipids, mediated by CD36, in CD8+ T lymphocytes leads to theirdysfunction and escalated cancer progression [1].This collaborative study, led by Dr. Susan Kaech, has found that in tumors killer Tcells accumulate oxidized lipids and switch to expressing immune-suppressive cellsurface molecules and cytokines.