HAVCR1 and urogenital neoplasm: KIM-1 possesses the properties of ideal marker of renal proximal tubule epithelium injury [70]: in the normal kidney, KIM-1 expression is determined in trace quantities; in ischemic or toxic kidney injury, activation of KIM-1 synthesis in the cells of the damaged tubules and its increased expression on the apical cell membrane is observed; shedding of KIM-1 from the cell surface results in considerable increase of its content in urine and/or in the circulating blood.