The aim of the study was to determine the molecular genetic prognostic criteria for the severity of pneumonia based on the analysis of the association of genetic polymorphisms of toll-like receptors (rs5743551 (TLR1), rs5743708 (TLR2), and rs4986790 (TLR4) loci) with the severity of NETosis. The gene discussed is TLR1; the disease is pneumonia.