RNLS and Hypertension: The results of a meta-analysis from 4 studies performed by Shi et al. (2015) indicated that RNLS rs2296545 polymorphism is not related to hypertension in none of genetic models [28], but another meta-analysis by Lv et al. (2016) on six studies showed the relationship between rs2296545 but not rs2576178 variants and higher risk of hypertension [29].