According to our KM survival curve analysis, we found that high expression of CDK1, CDC20, BUB1, BUB1B, CCNB1, NDC80, CENPF, MAD2L1, and NUF2 predicted worse survival outcome in patients with HCC (P < 0.05), but CCNB2 did not. The gene discussed is CENPF; the disease is hepatocellular carcinoma.