It has been shown that PTGS2 is associated with carotid plaque, platelet activation, and TXA2 levels [57] and is a target for the effects of smoking and alcohol consumption on stroke [58], and inhibition of PTGS2 can have a protective effect on MCAO mice through the NF-κB signaling pathway [59]. The gene discussed is NFKB1; the disease is stroke disorder.