MSH2 and cancer: As shown in Figure 7(a), PBK/TOPK expression was positively correlated with the expression of DNA mismatch genes, including MLH1, MSH2, MSH6, and PMS2, in the majority of cancers except CHOL and UCS (see Figure 7(a); for additional details, see Table S7), suggesting that PBK/TOPK may promote cancer progression by upregulating DNA mismatch repair-related genes.