MKI67 and neoplasm: Figure 2 indicates that DiAcSpm showed negative/weak staining in normal colon tissues. DiAcSpm expression was elevated in tumor tissues. In 96 cases, 67% (65/96) showed high DiAcSpm expressions.  Table 1 shows that high DiAcSpm levels significantly correlated with an advanced tumor node metastasis state (P=0.0022), positive nodal metastasis (P=0.038), and high Ki67 proliferation index (P=0.0041).