miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2, inhibits colorectal cancer angiogenesis and metastasis by regulating the NF90/VEGFA axis, inhibits gastric cancer cell growth and chemosensitivity through the RECK and AKT/ERK pathway, inhibits growth of HepG2 cells via decrease of S100A10 expression and inhibition of Wnt pathway, and suppresses the proliferation and invasion of NSCLC by regulating GAB1 [36, 37]. This evidence concerns the gene GAB1 and colorectal cancer.