Our data suggest that the RON-associated miRNAs may impact a number of pathways, including PI3K-Akt, MAPK, endocytosis, proteoglycans in cancer, focal adhesion, and Ras signaling pathway-related activation state; these pathways may be differentially activated between NSCLC samples that exhibit distinct patterns of RON expression and are consistent with previous research which suggested that RON promotes oral squamous cell carcinoma progression by regulating EMT and the MAPK signaling pathway [38]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.