It has been demonstrated that TrcP5-expressing poorly differentiated CRC cell lines including SW480, HT-29, SW620, DLD1, HCE8693, and RKO can upregulate Wnt5a and cytoplasmic β-catenin expression that finally lead to the decreasing differentiation and enhancing stemness of CRC cells [62]. Here, WNT5A is linked to colorectal carcinoma.