Since the tumor suppressors such as phosphatase and tensin homolog (PTEN) and Wnt5a have a highly conserved binding site for miR-26b, transfection of miR-26b mimic into the CRC cell lines stimulates metastasis of CRC cells via increasing EMT and downregulation of Wnt5a and PTEN [56]. This evidence concerns the gene PTEN and colorectal carcinoma.