HPGD and colorectal carcinoma: In line with this, treatment of CRC cell lines including HT-29 and Caco-2 with recombinant Wnt5a (rWnt5a) or Foxy-5, a Wnt5a mimicking peptide, shows that this recombinant can inhibit cell proliferation and stimulate cell differentiation through overexpression of a tumor suppressor enzyme in prostaglandin E2 catabolism named 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and reduction of Wnt β-catenin signaling [51].