In contrast to the inhibitory effect of Wnt5a-determining factors, including epigenetic modification-induced methylation of Wnt5a promoter, factors-stimulated overexpression of Wnt5a, and Wnt5a-induced overexpression of tumor suppressor genes, the stimulatory effect of Wnt5a on CRC samples has also been examined in several studies. This evidence concerns the gene WNT5A and colorectal carcinoma.