In contrast with these results, overexpression of Wnt5a in prostate cancer cell lines such as PC3 cells can significantly induce cell apoptosis and reduce cell proliferation and migration as well as modulate local tumor growth and tumor growth in the bone microenvironment, suggesting that Wnt5a can act as a tumor suppressor gene both in vivo and in vitro [38]. This evidence concerns the gene WNT5A and prostate carcinoma.