A regulator factor highly expressed in intestinal epithelial cells (IECs) in tumor microenvironment named calcium/calmodulin-dependent protein kinase ǀǀ gamma (CAMK2γ), which is known as a downstream target of Wnt5a noncanonical signaling induced by dextran sodium sulfate- (DSS-) induced colitis-associated cancer (CAC). This evidence concerns the gene WNT5A and neoplasm.