On the other hand, to assess the prognostic role of Wnt5a methylation and tumor subtypes, it has been observed that Wnt5a methylation has significantly associated with increasing microsatellite instability (MSI) tumors features, including one mismatch repair protein, MLH1 methylation, proximal location, mucinous histological type, and female gender [57]. The gene discussed is WNT5A; the disease is neoplasm.