Mechanistically, the autocrine activity of Wnt5a-stimulated M2 polarization of TAMs, as a TAM subtype, provokes cell proliferation, migration, and invasion of CRC cells, including HCT116 and DLD1, though increasing secreted interleukin-10 (IL-10) in TAM cells which is mediated by overactivation of CaMKǀǀ-ERK1/2-STAT3 signaling pathways [60]. The gene discussed is IL10; the disease is colorectal carcinoma.