We found that ADAMTSL5, ADAMTSL1, ADAMTS19, ADAMTS3, ADAMTS8, ADAMTS16, ADAMTS15, ADAMTS17, ADAMTSL2, and ADAMTS6 were low expressed in ccRCC and ADAMTS12, ADAMTS4, ADAMTS2, ADAMTS18, ADAMTS7, ADAMTS20, ADAMTS10, ADAMTS9, ADAMTSL4, ADAMTS14, ADAMTS5, and ADAMTS13 were highly expressed in ccRCC. The gene discussed is ADAMTSL5; the disease is nonpapillary renal cell carcinoma.