Although ADAMTSL5 is a risk factor for the prognosis of renal cell carcinoma, the change of its expression in KIRC has no significance in the analysis of gene expression changes across cancer types, so we do not analyze its pathway, and similarly, we do not analyze the pathway of ADAMTS3, ADAMTS6, and ADAMTS13. The gene discussed is ADAMTS6; the disease is hereditary clear cell renal cell carcinoma.