Functional annotation of the key modules showed a distinct biological significance bias for each module (Supplementary Table S2) for example, the “salmon” module (early infection of CD4+ T cells) was significantly enriched in inactivation of metabolic and infection-related pathways (Figure 2A), whereas the “orangered4” module (chronic infection of CD4+ cells) was most significantly enriched in the TGF-beta signaling pathway and IL-17 signaling pathway, among others (Figure 2B). This evidence concerns the gene CD4 and infection.