Numerous studies have focused on interpreting the RNA-seq profiles of gliomas in an attempt to elucidate their dynamics and mechanisms, with studies on recurrent glioblastoma able to distinguish comprehensive transcriptome profiling in the malignant progression of human gliomas (Zhao et al., 2017) and find critical clues of MET-related mutations (Hu et al., 2018) and oncogenic fusions (Bao et al., 2014). Here, MET is linked to central nervous system cancer.