Activities associated with several interleukins (ILs), including IL-6, IL-8, and IL-10, were enriched in negative immune response clusters (Figure 3C), with IL-8 expression negatively correlated with GBMs survival and positively correlated with the expression of genes associated with the glioblastoma-initiating cell phenotype, as well as the possibility of GBM recurrence (Hasan et al., 2019). This evidence concerns the gene IL6 and glioblastoma.