Remarkably, CTD-3184A7.4, also termed as MHENCR, and RP11-108L7.15 have been reported to promote melanoma progression via PI3K-Akt signaling (Chen et al., 2017), and cell proliferation, migration and invasion in glioblastoma (Shi et al., 2017), further suggesting that these lncRNAs might play functional roles in COAD progression. Here, AKT1 is linked to colon adenocarcinoma.