Consistently, we observed that most of the m6A readers (YTHDF3, IGF2BP2, HNRNPA2B1, HNRNPC, RBMX, YTHDF1, and IGF2BP3) and 21 m6A-related lncRNAs were upregulated in subtype 3, suggesting that the m6A readers and the m6A-related lncRNAs might be associated with metabolic reprogramming and unfavorable outcomes in COAD. The gene discussed is YTHDF1; the disease is colon adenocarcinoma.