Regarding the most downregulated cancer type in the two datasets, the coexpression genes of CST6 (Pearson correlation > 0.3) were commonly shared between MMDs lung cancer and TCGA LUAD/LUSC datasets, showing a statistically significant overlap (Figure 2B, hypergeometric test, p-value < 2.2e-16). The gene discussed is CST6; the disease is lung cancer.