Nonetheless, a four-novel-gene-based prognostic model to predict the patients with a high-risk HCC excluded DNASE1L3 because no statistical association was found between DNASE1L3 and the patient survival (Dessie et al., 2021), while our study sufficiently showed that DNASE1L3 is an independent prognostic predictor of HCC. This evidence concerns the gene DNASE1L3 and hepatocellular carcinoma.