The most frequent Akt mutation is found in its PH (pleckstrin homology) domain identified in cancers such as bladder, lung, pancreatic, endometrial, and urothelial (Malanga et al., 2008; Mohamedali et al., 2008; Shoji et al., 2009; Zilberman et al., 2009; Askham et al., 2010). The gene discussed is AKT1; the disease is cancer.