E2F transcription factors (E2F3), which can interact with histone acetyltransferase and induce cells to enter the cell cycle, participated in the development and progression of many tumors, such as pancreatic cancer and ovarian cancer (Kurtyka et al., 2014; Rotgers et al., 2014; Park et al., 2015; Pengcheng et al., 2021; Xu D. et al., 2021). The gene discussed is E2F3; the disease is familial pancreatic carcinoma.