The cBioPortal database was used to analyze the mutations of seven genes, which showed that E2F3, ETS2, HLF, HSF4, KLF4, MEIS2, and TCF7L1 were altered in 8, 8, 6, 6, 5, 9, and 6% of 524 colorectal adenocarcinoma patients separately (Supplementary Figure S3A). Here, KLF4 is linked to colorectal adenocarcinoma.