The upregulated hub genes ADCY2, CXCL12, and GNB4 were enriched in calcium signal pathway, dilated cardiomyopathy, hypertrophic cardiomyopathy, neuroactive ligand-receptor interaction pathway, and vascular smooth muscle contraction pathways related to cardiomyopathy (Figure 6D). Here, GNB4 is linked to dilated cardiomyopathy.