NUPR1 and cardiac hypertrophy: Moreover, NUPR1, a nuclear protein, is strongly induced by stress response (Goruppi and Iovanna, 2010) and is related to transcriptional regulation, cardiac hypertrophy, cell cycle control, and apoptosis regulation (Vasseur et al., 2002; Quirk, Seachrist, and Nilson, 2003; Kong et al., 2010; Georgescu et al., 2011).