GSEA analysis results showed that down-regulated hub genes IL-1B, IL-1A, and CXCL4 were enriched in the ubiquitin-mediated proteolysis signal pathway and oxidative phosphorylation pathway related to biological behavior (Figure 6A); the upregulated hub genes ADRA1A, AVPR1B, and OPN4 were enriched in the calcium signal pathway, extracellular matrix (ECM) receptor interaction, dilated cardiomyopathy, and hypertrophic cardiomyopathy (Figure 6B). Here, OPN4 is linked to hypertrophic cardiomyopathy.