Compared with m6A cluster A, we observed that m6A cluster B was charactered by higher infiltration levels of activated CD4 T cells, activated dendritic cells, central memory CD8 T cells, Effector memory CD4 T cells, eosinophils, immature B cells, immature dendritic cells, mast cells, neutrophils, regulatory T cells, and type 2 T helper cells, demonstrating higher immunogenicity in m6A cluster B. Consistently, previous studies have reported the interactions between m6A and tumor microenvironment of pancreatic cancer. This evidence concerns the gene CD8A and familial pancreatic carcinoma.