Compared with m6A cluster A, we observed that m6A cluster B was charactered by higher infiltration levels of activated CD4 T cells, activated dendritic cells, central memory CD8 T cells, Effector memory CD4 T cells, eosinophils, immature B cells, immature dendritic cells, mast cells, neutrophils, regulatory T cells, and type 2 T helper cells, demonstrating higher immunogenicity in m6A cluster B. Consistently, previous studies have reported the interactions between m6A and tumor microenvironment of pancreatic cancer. The gene discussed is CD8A; the disease is pancreatic neoplasm.