Jian et al. (2020) indicated hsa_circ_001680 was highly expressed in CRC tissue, which could enhance the capacity of cell proliferation and migration. Additionally, hsa_circ_001680 promoted the cancer stem cell population and induced irinotecan resistance by regulating miR-340 to affect BMI1 expression (Jian et al., 2020). The gene discussed is BMI1; the disease is cancer.