TGFB1 and colorectal carcinoma: In the study, KEGG pathway analysis in HCT8/DDP cells showed that DE-circRNAs may affect many pathways such as Hippo, transforming growth factor-β (TGF-β), and mitogen-activated protein kinase (MAPK) signaling pathway, among them Hippo signaling pathway was the most enriched pathways, which may be related to the process of cisplatin resistance in CRC.