Another OA risk gene ITIH3 (POA = 2.59 × 10–7, PMD = 5.27 × 10–6) interacts with antipsychotics clozapine (Brandl et al., 2016) and has been linked to depression (Amare et al., 2020), schizophrenia (Ikeda et al., 2018), and ASD (Xie et al., 2020), among other disorders. The gene discussed is ITIH3; the disease is major depressive disorder.