Similar to DRD2, NRXN1 interacts with a range of psychiatric medications such as duloxetine, which is used for MD, generalized anxiety disorder (GAD), fibromyalgia, chronic musculoskeletal pain, and osteoarthritis of the knee (Jenkins et al., 2014; Maciukiewicz et al., 2018). Here, NRXN1 is linked to osteoarthritis.