This is because, in addition to its intracellular functions, the IL-27 heterodimeric cytokine, which uses EBI3 as one of its subunits, has both antitumor and protumor activities (60) and the IL-35 cytokine mainly has protumor activity by inducing immune suppression, and enhancing tumor angiogenesis and myeloid cell accumulation (61–63). This evidence concerns the gene EBI3 and neoplasm.