NLRP3 and gout: Indeed, this family of molecules was shown to inhibit the activation of the Nlrp3 (NOD-like receptor family, pyrin domain containing 3) inflammasome (see below) in murine bone marrow-derived macrophages, an effect that could very well account for their anti-inflammatory properties and efficacy against gout, a disease in which the NLRP3 inflammasome has been strongly implicated (37, 38).