MAPK8 and AIDS: Furthermore, with the increasing mortality induced by antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), whose mortality is similar to that of acquired immune deficiency syndrome (AIDS) (41), whether the K+ efflux/Syk/JNK/NEK7-NLRP3 signaling pathway can be activated to defend against MRSA infection remains unknown.