IgD+CD27+ unswitched MBCs usually present anti-inflammatory properties, for instance, are reduced in systemic lupus erythematosus (26), primary Sjögren’s Syndrome (pSS) (19), and reconstitute after immunosuppressive treatment, this phenomenon also is observed in IgG4-RD in our study. This evidence concerns the gene CD27 and immunoglobulin G4-related sclerosing disease.