CCL5 and neoplasm: The hypoxic condition induces the production of a broad array of migratory stimulating factors, such as VEGF, CCL2, CCL5, CSF-1, EMAP-II, endothelin-2, SEMA3A, oncostatin M, and eotaxin, in tumor cells and the stroma within oxygen-deprived regions (17–24), resulting in macrophage recruitment and entrapment (25).