The interaction between SIRPα and CD47, expressed on both APCs and pancreatic β-cells, might represent a key factor in T1D pathogenesis, and studies are warranted to examine their in situ expression in the human pancreas from control and T1D donors, impact on insulin production, and eQTL epistasis from single-cell sequencing data (92). Here, CD47 is linked to type 1 diabetes mellitus.