These in vitro observations warrant further investigation of how SIRPγ:CD47 signaling might play a role in modifying cell migration using ex vivo platforms to study human pancreas (78–80) samples or humanized mouse models (81) xenografted with human cells to explore potential implications for islet infiltration and the development of insulitis in human T1D. Here, SIRPG is linked to type 1 diabetes mellitus.