Hence, this review will examine the SIRP:CD47 family signaling axis and its potential role in T1D pathogenesis, centering on the impacts of SIRPα, SIRPγ, and CD47 on immune cell function, along with that of SIRPα and CD47 on β-cell survival and insulin production (Figure 3). Here, SIRPG is linked to type 1 diabetes mellitus.