Tseng and colleagues further demonstrated that treatment of the DLD1 human colon cancer cell line with anti-CD47 blocking antibody (clone B6H12) facilitated their phagocytosis by macrophages, which subsequently increased their ability to prime CD8+ T cells for proliferation and cytotoxicity as compared to macrophages cultured with DLD1 cells in the absence of anti-CD47 (63). This evidence concerns the gene CD47 and malignant colon neoplasm.