C3 and central nervous system cancer: We then performed timeROC curves validation of the 4 hub genes, and the results showed that the AUC of C3, TCF12, and IDH1 genes were all greater than 0.6, and the AUC of TP53 was greater than 0.5, further indicating that these four genes have an important role in the prognosis of glioma (Figures S1A-D).