Previous reports showed that the frequencies of cTfh cells characterized byCXCR5+ICOS+PD-1+progressively increased up to 20 days from the onset of infection in a case with non-severe convalescent COVID-19, in addition to elevated specific plasma SARS-CoV-2-binding IgM and IgG antibodies (145). The gene discussed is CD40LG; the disease is COVID-19.