CHMP5 and COVID-19: Additionally, a single-cell transcriptomic analysis revealed that increased proportions of cytotoxic cTfh cells in hospitalized COVID-19 patients early in the illness are negatively correlated with the IgG levels of anti-spike protein antibodies to SARS-CoV-2, although the total SARS-reactive cTfh cells show a positive correlation with anti-spike antibody levels in hospitalized COVID-19 patients but not in non-hospitalized COVID-19 patients, which provided insights into cytotoxic cTfh cells in the distinct disease severities of COVID-19 patients (155).