IRF3 and infection: HSV-1 tegument proteins VP11/12 (34) and VP22 (35), and the IE expressed protein ICP27 (36), counteract the host protein STING (stimulator of interferon genes, a cytosolic DNA sensor/signal mediator) and its signaling though TBK1 (TANK-binding kinase 1) and IRF3 (interferon regulatory factor 3) in the early innate immune response to infection.