Next, we conducted a similar analysis on the TCGA-NSCLC cohort (Figure 2B), and the results showed that the TNFα-MT group had a significantly higher frequency of somatic mutations, including all 20 with the highest mutation frequencies (P < 0.05), but the only tumor suppressor gene included in these mutations was TP53. Here, TP53 is linked to non-small cell lung carcinoma.