CD14 and dengue disease: In a previous study, a differentially expressed TLR profile was reported in children with severe dengue, wherein increased expression of TLR7 and TLR4 transcript variant 3 (TLR4R3) and decreased expression of TLR1, TLR2, TLR4R4, and TLR4 cofactor CD14 were observed (de Kruif et al., 2008).