Insulin resistance correlates with the development of microalbuminuria in patients with T2DM, for insulin resistance per se contributes to higher salt sensitivity, which closely associates with increase in blood pressure, albuminuria and renal function decline (32, 33).Generally considered, ANGPTL8 may drive the progression of DN through pathways and mechanisms related to insulin resistance. The gene discussed is ANGPTL8; the disease is liver dysplastic nodule.