However, there are contradictory of findings with respect of serum level of ANGPTL8 in T2DM, some studies reported that ANGPTL8 was increased in T2DM individuals (12, 13) in contrast with a lower concentration of ANGPTL8 reported by Gomez−Ambrosi et al (14). This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.