Furthermore, logistic regression analysis indicated that there was nearly 3-fold and 4-fold increased risk of DN respectively in higher ANGPTL8 level (OR=2.713, 95% CI 1.494-4.926 P=0.001) and higher resistin level (OR=4.248, 95% CI 2.260-7.987 P<0.001) in the non-NAFLD population, and this association still existed after multiple adjustment (Table 4). This evidence concerns the gene ANGPTL8 and liver dysplastic nodule.