One particular study concluded that kidney damage evidenced by abnormal renal morphology was directly associated with hyperglycemia-induced oxidative stress in diabetic db/db mice, while oligonol exhibits anti-diabetic effect, reducing glomerular hypertrophy and mesangial matrix expansion caused by diabetes, through down-regulation of circulating resistin and IL-6 levels, demonstrating that kidney damage was able to be protected via suppressing inflammatory markers (46). This evidence concerns the gene RETN and Hyperglycemia.