Obesity per se seemed not to be associated with elevated afamin, since neither BMI (p=0.764) nor body weight (p=0.803), waist circumference (p=0.908), % of body fat (p=0.740), visceral (p=0.693), subcutaneous adipose tissue (p=0.516), adipocyte diameter (p=0.903) had a significant contribution in a regression model consisting of age, hepatic lipids, and fasting insulin. The gene discussed is INS; the disease is Obesity.