Positive correlations were found between afamin and determinants of obesity (BMI, body weight, % of body fat), abdominal adiposity (waist circumference, subcutaneous and visceral adiposity), subcutaneous adipocyte diameter (fat cell size), systemic markers of metabolic overload and metabolic disorders e.g. fasting triglycerides, insulin, C-peptide, glucose, HOMA-IR, atherogenic index, hsCRP, FFA, area under the glycemic, insulinemic and C-peptide curve (oGTT). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.