INS and hyperinsulinism: However, it is worth noting that patients with primary insulin resistance, characterized by marked hyperinsulinemia and genetically dysfunctional insulin receptor, namely, those with type A insulin resistance, Rabson–Mandenhall syndrome, or Leprechaunism, may have close to normal glucose tolerance, retain normal weight, and normotrygliceridemic, in spite of congenital significantly elevated plasma insulin concentrations (53).