However, it is worth noting that patients with primary insulin resistance, characterized by marked hyperinsulinemia and genetically dysfunctional insulin receptor, namely, those with type A insulin resistance, Rabson–Mandenhall syndrome, or Leprechaunism, may have close to normal glucose tolerance, retain normal weight, and normotrygliceridemic, in spite of congenital significantly elevated plasma insulin concentrations (53). This evidence concerns the gene INS and Hyperinsulinemia.