Here, H&E staining revealed the obvious inflammatory cell infiltration, cytoplasm relaxation, and vacuolar degeneration of hepatocytes in DSS-induced colitis mice, which was confirmed by the enhancement of pro-inflammatory cytokines (TNF-α, IFN-γ, and IL-17A) using IHC, qRT-PCR, and western blot analysis. Here, IL17A is linked to colitis.