In HFD-induced obese mice, the lipid-lowering effect, as well as the anti-obesity potential of BBR, are associated with the increase of serum TCA level and the intestinal FXR activation, however, BBR fails to prevent HFD-induced obesity in intestine-specific FXR knockout mice (Sun et al., 2017). Here, NR1H4 is linked to obesity due to melanocortin 4 receptor deficiency.