AKT1 and hepatitis B virus infection: As is revealed in pharmacological mechanisms, the KEGG pathways of Pachyman in treating HCC included the following: pathways in cancer, proteoglycans in cancer, bladder cancer, hepatitis B, pancreatic cancer, PI3K-Akt signaling pathway, Rap1 signaling pathway, Ras signaling pathway, estrogen signaling pathway, MAPK signaling pathway, toxoplasmosis, microRNAs in cancer, hepatitis C, amyotrophic lateral sclerosis (ALS), chemokine signaling pathway, viral carcinogenesis, focal adhesion, VEGF signaling pathway, apoptosis, and regulation of actin cytoskeleton (Figures 4A–C).