Additionally, anti-proliferation pathways (such as apoptosis, and PI3K-Akt and MAPK signaling pathways), anti-invasiveness pathway (such as Ras and Rap1 signaling pathway), anti-angiogenesis pathway (such as VEGF signaling pathway), and other pathways (such as MicroRNAs in cancer) were all identified in Pachyman treating HCC actions, as revealed in the KEGG-based findings. This evidence concerns the gene VEGFA and hepatocellular carcinoma.