Clinically proven medicines for treating T2DM include thiazolidinediones (Thangavel et al., 2017; Nanjan et al., 2018; Oikonomou et al., 2018) as well as sulfonylureas, which stimulate insulin secretion and increase insulin sensitivity to biguanides (Setter et al., 2003). Here, INS is linked to type 2 diabetes mellitus.