Further in vitro antidiabetic trials demonstrated that a predicted antidiabetic ingredient from Ge-Gen, 4-hydroxymephenytoin, can increase the insulin secretion in RIN-5F cells and improve insulin resistance in 3T3-L1 adipocytes (Li et al., 2014), indicating that the network pharmacology strategy is a powerful means for identifying bioactive ingredients and mechanisms of action for TCM herbal formulae. This evidence concerns the gene INS and Insulin resistance.