Although HPT is known to significantly inhibit IL-1β-induced inflammatory responses in human chondrocytes during osteoarthritis (Lin et al., 2020), it remains unknown whether exogenously applied HPT is capable of reversing TNF-α-induced abnormal expression of genes and proteins to prevent the degradation of articular cartilages induced by ACLT transection injury. This evidence concerns the gene IL1B and osteoarthritis.