Recent evidence also supported that SCD1 involved in many tumor-related pathways and played important roles in the self-renewal, metastasis, and resistance to therapy in glioblastoma, breast, lung and bladder CSCs (Noto et al., 2013; Colacino et al., 2016; Li J. et al., 2017; Mukherjee et al., 2017; Noto et al., 2017; Pisanu et al., 2018; Pinkham et al., 2019; Gao et al., 2020; Yu et al., 2021). This evidence concerns the gene SCD and glioblastoma.