ACE and heart failure: Sacubitril/valsartan (Sac/Val) is an angiotensin receptor-neprilysin inhibitor (ARNI) that reduces the risk of death and hospitalization of patients with heart failure, and researches show that it is superior to angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) in alleviating heart failure (Lefer and Sharp, 2018; Velazquez et al., 2019).