Dysfunction of the NLRP3 inflammasome is implicated in various inflammatory diseases, such as type 2 diabetes (Masters et al., 2010), neuron degenerate diseases (Halle et al., 2008; Venegas et al., 2017; Ising et al., 2019) and gout (Martinon et al., 2006). This evidence concerns the gene NLRP3 and gout.