Previous magnetic resonance imaging (MRI)-based studies have demonstrated that subjects with psychiatric disorders (Lizano et al., 2019), complex regional pain syndrome (Zhou et al., 2015), multiple sclerosis (Ricigliano et al., 2021) and stroke (Egorova et al., 2019), have larger CP volumes compared to healthy controls, whereas studies evaluating CP size in participants without any sign of pathology have only looked at thickness. The gene discussed is CP; the disease is complex regional pain syndrome.