While it has been observed that epithelial cell growth of the CP slows with age in younger animals (McDonald and Green, 1988; Liddelow et al., 2010), previous reports have demonstrated that enlarged ventricles and increasing inflammation due to stroke or direct tissue injury upregulated CP-derived growth factors resulting in volume proliferation of CP epithelial cells (Li et al., 2002; Barkho and Monuki, 2015). Here, CP is linked to stroke disorder.