First, the cortical predominantly amyloid deposition in patients with late-onset sporadic AD may be influenced by synaptic processes, whereas in EOFAD, amyloid deposition in subcortical areas, such as the striatum, may be mediated by amyloid precursor protein and its processing (Koivunen et al., 2008; Ishibashi et al., 2014). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.